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Spatial distribution of the immune infiltrate as a putative predictor of recurrence type in triple negative breast cancer
Dr. Nina Radosevic-Robin, Pathologist at Clermont Auvergne University-INSERM presents.

Spatial genomics is a powerful tool to shed light on the complexity and diversity of the immune context of the tumor microenvironment. In her live webinar, Dr. Nina Radosevic-Robin will present how the GeoMx™ DSP is a very useful tool in biomarker discovery for precision oncology and that Spatial distribution of certain TME cell subtypes as well as immune characteristics of tumor cells are worth further exploration as recurrence/aggressiveness biomarkers of TNBC.

Analyzing FFPE tumor tissues samples of six triple negative (ER-/PR-/HER2-) breast cancers (TNBCs) representing tumors with different clinical behaviors: metastatic at diagnosis or rapidly recurring after neoadjuvant cytotoxic treatment (MR group, 3 samples) or without recurrence at all after such a treatment (NR group, 3 cases). Her team observed that tumor periphery and tumor center greatly differed, in terms of tumor or TME characteristics, and that these features were associated with specific tumor clinical behavior.

Join us in this webinar to listen to the most interesting findings from this study:

MR tumors had higher numbers of mesenchymal-derived suppressor cells (MDSC) in the center and lower numbers of the M1-type (CD68+) macrophages at the periphery, compared to NR tumors. In addition, peripheral tumor cells in MR group had much lower expression of HLA-DR than tumor cells in NR group. Segmentation by the instrument, on T and TME areas was crucial for easy and correct observation of these differences.
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